The body responds to tissue injury, genetic changes, and infection through pain and inflammation. These responses can be either acute or chronic. If the condition causing inflammation or pain is not resolved, it progresses. This causes immunopathological changes such as overexpression of pro-inflammatory genes and dysregulated cellular signaling. Cannabidiol has been successfully transformed from herbal preparations into creams, oils, tinctures, and foods for faster pharmacokinetics.
CBDs’ direct effects on the endocannabinoid system of receptors enhance other brain chemicals’ effects to reduce pain and suppress inflammation. Therefore, it is a suitable treatment method for epilepsy, anorexia, sleep disorders, Alzheimer’s, and Parkinson’s disease. Feasible delivery modes of CBD have been identified through research and have shown high efficacy, dose ranges, and safety. Through controlled clinical trials, delivery modes of CBD for short-term, acute injury, or sore areas have been identified to be the following:
Cannabinoids administered through inhalation express a high rate of bioavailability, depending on the individual. Delivery of CBD through vaporizers results in a high onset time, more intense effects, and longer duration periods. Through this method, CBD reaches the maximum concentration in the blood after administration. This method is highly preferred because of the fast absorption times, convenience, and accuracy of dosing.
Transformation of cannabinoids from herbal products into food products allows administration of CBD through the mouth. CBD concentrates present in food take a relatively long period to reach a maximum concentration in the blood. This is due to the first-pass metabolism. The effects take a long time to occur as the liver enzymes need to break the CBD down before it is absorbed by the body. Oral administration is suitable for patients with chronic diseases.
CBD packaged as cream or ointment in dermal patches shows a slow absorption rate with a long-lasting effect. It takes a longer time to reach a maximum peak in plasma as compared to other routes. This route is highly recommended for treating superficial inflammation such as acne, wounds, and insect bites.
The rectal mucosa has a low absorption rate of cannabinoids. This delivery method is only used in patients who have problems with topical application, oral, and inhalation routes. Though it is not regularly used, studies are being conducted to allow faster absorption of synthetic cannabinoids.
If you plan on using CBD, it is crucial to understand the different ways to administer it. Each formulation has different rates of bioavailability, speed of absorption, and duration of effects. The most common formulations include:
Having described the best delivery modes for CBD, we recommend that you consult your doctor to decide what’s best for you. Consulting a professional helps reduce instances of overdose and allergic reactions. The downside of the routes discussed above include:
Inhalation is associated with bronchitis, chronic cough, and carbon intoxication.
It is difficult to control the dosage of edible products.
Creams applied through the topical application are potential causes of allergic skin reactions.
Rectal administrations for chronic patients are highly uncomfortable.
Contact Made by Hemp to find CBD wellness products for your short-term injuries.
These statements have not been evaluated by the food and drug administration (FDA). These products are not intended to diagnose, treat, cure or prevent any disease.