Reasons You Should Never Mix CBD With These Medications

Cannibidol, more commonly known as CBD, received a lot of attention even before its official legalization in 2018. The reason people have put it in the spotlight is because CBD has been able to treat things such as anxiety and inflammation. Scientists and doctors have found that CBD is typically safe to take with little side effects.

However, people may find it helpful to mix CBD with certain medications. This should not be done as mixing CBD with other medications can sometimes cause more harm than good. Below are several medications you should never mix with CBD.


Clobazam is a medication used to treat seizures. Mixing CBD with this medication can heighten its effects. Since clobazam is a sedative, mixing it with CBD products could cause over sedation, which can result in decreased respiratory effort. For this reason, you should never combine the two.


Theophylline is a medication that treats respiratory issues such as asthma and bronchitis. Smoking marijuana, which contains CBD, could possibly reduce the efficiency of the drug. This happens by increasing the rate of metabolic clearance, which basically means your body clears the medication out faster.

However, it is not currently known if this effect is a result of the marijuana or smoking as a whole. Numerous studies have shown that tobacco use has this effect as well. There is no evidence products such as CBD oil or CBD gummies increase your metabolic clearance.


Warfarin is a type of blood thinner medication that should never be mixed with anything, much less CBD. CBD can dramatically increase your risk of bleeding while on Warfarin. Not only that, but it also increases the chance of you developing thrombosis, which are blood clots that can travel to your heart, lungs or brain.

Similar to the CYP2C19 enzyme and Clobazam, mixing CBD with Warfarin can “excite” the CYP2C9 enzyme. In turn, this causes it to increase the amount of Warfarin. Warfarin is meant to be taken in low doses unless specifically stated otherwise by your doctor.

While CBD does offer a variety of positive benefits, like helping to reduce pain and inflammation and even possibly treating seizures, you also need to know the risk of combining CBD with other medications. Make sure to ask your doctor if it is safe to use CBD in conjunction with your other medications.

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